The main aim of the present study was to develop diclofenac potassium tablets by wet granulation technique using different concentration of natural binder Aloe barbadensis miller mucilage. Prepared formulations were evaluated for precompressional parameter such as hardness, friability, angle of repose, disintegration test. The formulation prepared with Aloe barbadensis miller mucilage showed disintegration time of 50 min. The result concluded that compression tablet of poorly water soluble drug; diclofenac potassium showed enhanced disintegration, which leads to improved bioavaibility, improved effectiveness and hence better patient compliance by using natural binder like Aloe barbadensis miller mucilage.
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